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The iPhone 6s and 6s Plus were made with series aluminum a design flaw nicknamed "Bendgate" , and as a byproduct of this lack of rigidity, the touchscreen's internal hardware being susceptible to losing its connection to the phone's logic board nicknamed "Touch Disease".
The iPhone 6 Plus was also the subject of camera issues, including some devices with malfunctioning optical image stabilization or otherwise defects on rear cameras.
Their spot as the entry-level iPhone was replaced by the iPhone SE , which was released earlier on March 31, From the launch of the original iPhone to the iPhone 4S , iPhones used 3.
The iPhone 5 and its immediate successors featured a display that was taller, but the same width as prior models, measuring at 4 inches diagonally.
Following Apple's loss in smartphone market share to companies producing phones with larger displays, reports as early as January suggested that Apple was preparing to launch new iPhone models with larger, 4.
In August , Apple admitted that some iPhone 6 Plus models may have faulty cameras that could be causing photos to look blurry and initiated a replacement program.
In June , Apple faced a potential sales ban in China, as Shenzhen Baili, a Chinese device maker, alleged that the iPhone 6 and iPhone 6 Plus infringed on its design patent.
As the iPhone SE has more powerful internal hardware than the midrange iPhone 6 largely the same as the 6S and had been released earlier on March 31, , this created an unusual situation when it was sold alongside the iPhone 6 and 6 Plus until September 7 despite being marketed as a lower-tier iPhone.
In India it was sold on Amazon's website in Space Grey. In Taiwan, it was sold through Taiwan Mobile on March 10 in gold colour.
These are not being distributed by Apple on their website or their retail stores. The design of the iPhone 6 and iPhone 6 Plus is influenced by that of the iPad Air with a glass front that is curved around the edges of the display, and an aluminum rear that contains two plastic strips for the antenna.
The iPhone 6 has a thickness of 6. The most significant changes to the iPhone 6 and iPhone 6 Plus are its displays; both branded as " Retina HD Display " and "ion-strengthened", the iPhone 6 display is 4.
The displays use a multiple-domain LCD panel, dubbed "dual-domain pixels"; the RGB pixels themselves are skewed in pattern, so that every pixel is seen from a different angle.
This technique helps improve the viewing angles of the display. To accommodate the larger physical size of the iPhone 6 and iPhone 6 Plus, the power button was moved to the side of the phone instead of the top to improve its accessibility.
Unlike the previous model, the rear-facing camera is not flush with the rear of the device, but instead protrudes slightly. Both models include an Apple A8 system-on-chip , and an M8 motion co-processor—an update of the M7 chip from the iPhone 5s.
The primary difference between the M8 and the original M7 coprocessor is that the M8 also includes a barometer to measure altitude changes.
Early hands-on reports suggested that the A8's GPU performance might indeed break away from previous generations doubling of performance at each yearly release, scoring Wi-Fi performance has been improved with support for It is initially used exclusively for Apple Pay —a new mobile payments system which allows users to store their credit cards in Passbook for use with online payments and retail purchases over NFC.
The iPhone 6's rear-facing camera now has the ability to shoot p video at either 30 or 60 frames per second and slow-motion video at either or frames per second.
The camera also includes phase detection autofocus. The iPhone 6 Plus camera is nearly identical, but also includes optical image stabilization.
Apps are able to take advantage of the increased screen size in the iPhone 6 and 6 Plus to display more information on-screen; for example, the Mail app uses a dual-pane layout similar to its iPad version when the device is in landscape mode on the iPhone 6 Plus.
As it uses an identical aspect ratio, apps designed for the iPhone 5 , iPhone 5C, and 5S can be upscaled for use on the iPhone 6 and 6 Plus.
To improve the usability of the devices' larger screens, an additional "Reachability" gesture was added; double-tapping the Home button will slide the top half of the screen's contents down to the bottom half of the screen.
This function allows users to reach buttons located near the top of the screen, such as a "Back" button in the top-left corner.
Both iPhone 6 models received generally positive reviews. However, the plastic antenna strips on the rear of the phone were criticized for resulting in poor aesthetics, the display for having lower resolution and pixel density in comparison to other recent smartphones — including those with the same physical screen size as the iPhone 6, such as the HTC One , and for not having a sufficient justification for its significantly higher price in comparison to similar devices running Android or Windows Phone.
Improvements such as performance, battery life, VoLTE support, and other tweaks were also noted. In regards to the 6 Plus, Engadget panned its design for being uncomfortable to hold and harder to grip in comparison to other devices such as the Galaxy Note 3 and LG G3 , but praised its inclusion of optical image stabilization and slightly better battery life than the 6.
The iPhone 6 and 6 Plus were affected by a number of notable hardware-related issues, including but not limited to concerns surrounding their rigidity which led to incidents surrounding chassis bending, as well as degradation or outright loss of touchscreen functionality , performance issues on models with larger storage capacity, camera problems on the 6 Plus model, as well as an initially undocumented "error 53" that appeared under certain circumstances.
Shortly after its public release, it was reported that the iPhone 6 and iPhone 6 Plus chassis was susceptible to bending under pressure, such as when carried tightly in a user's pocket.
While such issues are not exclusive to the iPhone 6 and 6 Plus, the design flaw came to be known among users and the media as " Bendgate ". Apple responded to the bending allegations, stating that they had only received nine complaints of bent devices, and that the damage occurring due to regular use is "extremely rare.
On October 1, , it was reported by Axel Telzerow, editor-in-chief of the German technology magazine Computer Bild , that following the posting of a video where a presenter was able to bend an iPhone 6 Plus, an Apple Germany representative informed the publication that it had been banned from future Apple events and that it would no longer receive devices directly from Apple for testing.
Telzerow responded by saying that "we congratulate you to your fine new generation of iPhones, even if one of them has a minor weakness with its casing.
But we are deeply disappointed about the lack of respect of your company. On October 3, 9to5Mac released a post claiming that certain iPhone 6 and iPhone 6 Plus users complained on social networking sites that the phone ripped off their hair when they held the phone close to their ears when making phone calls.
Business Korea reported that the issues were connected to the triple-layer cell NAND storage of the affected models. Triple-layer cells can store three bits of data per cell of flash, and are cheaper than dual-layer cell solutions, but at the cost of performance.
It was reported that Apple had planned to switch the affected model lines back to multi-layer cell flash, and address the performance issues on existing devices in a future iOS update.
It was reported that the optical image stabilization systems on some iPhone 6 Plus models were faulty, failing to properly stabilize when the phone is being held perfectly still, leading to blurry photos and "wavy"-looking videos.
On August 21, , Apple instituted a repair program for iPhone 6 Plus models released between September and January , citing that faulty rear cameras on affected models may produce blurry pictures.
Some iPhone 6 and iPhone 6 Plus models have an issue in which the front-facing camera is somehow "shifted", or out of place. Apple stated that they would replace most affected iPhone 6 models with this issue, free of charge.
Despite numerous complaints regarding this issue, it does not seem to actually affect the camera itself. It is said that the camera is not what has shifted, but a piece of protective foam around the camera module itself that has gone out of place.
If the iPhone 6 home button is repaired or modified by a third party, the device will fail security checks related to Touch ID as the components have not been "re-validated" for security reasons—a process which can only be performed by an authorized Apple outlet.
Failing these checks disables all features related to Touch ID. Such effects have sometimes happened as a result of damage as well.
It was reported these same hardware integrity checks would trigger an unrecoverable loop into "Recovery Mode" if iOS is updated or restored, with attempts to restore the device via iTunes software resulting in an "error 53" message.
Beyond the explanation that this is related to hardware integrity errors regarding Touch ID components, Apple provided no official explanation of what specifically triggers error 53 or how it can be fixed without replacing the entire device.
On February 18, , Apple released an iOS 9. Touchscreen control components on iPhone 6 logic boards have insufficient support, including a lack of underfill—which strengthens and stabilizes integrated circuits , and a lack of rigid metal shielding on the logic board unlike previous iPhone models; the touchscreen controller is instead shielded by a flexible "sticker".
Normal use of the device can cause the logic board to flex internally, which strains the touchscreen IC connectors and leads to a degradation or outright loss of touchscreen functionality.
A symptom that has been associated with this type of failure is a flickering grey bar near the top of the display. As such, the larger iPhone 6 Plus is more susceptible to the flaw, but it has also been reported on a small percentage of iPhone 6 models.
Initially, Apple did not officially acknowledge this issue. The issue was widely discussed on Apple's support forum—where posts discussing the issue have been subject to censorship.
Apple Stores are not equipped with the tools needed to perform the logic board repair, which had led to affected users sending their devices to unofficial, third-party repair services.
An Apple Store employee interviewed by Apple Insider reported that six months after they first started noticing the problem, Apple had issued guidance instructing them to tell affected users that this was a hardware issue which could not be repaired, and that their iPhone had to be replaced.
However, some in-stock units have also been afflicted with this issue out of the box, leading to an employee stating that they were "tired of pulling service stock out of the box, and seeing the exact same problem that the customer has on the replacement".
On August 30, , a group of three iPhone 6 owners sued Apple Inc. On November 17, , Apple officially acknowledged the issue and announced a paid repair program for affected iPhone 6 Plus models, stating that "some iPhone 6 Plus devices may exhibit display flickering or Multi-Touch issues after being dropped multiple times on a hard surface and then incurring further stress on the device".
From Wikipedia, the free encyclopedia. September 19, . IL-6 is also considered a myokine , a cytokine produced from muscle, which is elevated in response to muscle contraction.
IL-6 has extensive anti-inflammatory functions in its role as a myokine. IL-6 was the first myokine that was found to be secreted into the blood stream in response to muscle contractions.
IL-6 was serendipitously discovered as a myokine because of the observation that it increased in an exponential fashion proportional to the length of exercise and the amount of muscle mass engaged in the exercise.
It has been consistently demonstrated that the plasma concentration of IL-6 increases during muscular exercise.
This increase is followed by the appearance of IL-1ra and the anti-inflammatory cytokine IL Following exercise, the basal plasma IL-6 concentration may increase up to fold, but less dramatic increases are more frequent.
The exercise-induced increase of plasma IL-6 occurs in an exponential manner and the peak IL-6 level is reached at the end of the exercise or shortly thereafter.
It is the combination of mode, intensity, and duration of the exercise that determines the magnitude of the exercise-induced increase of plasma IL IL-6 had previously been classified as a proinflammatory cytokine.
Therefore, it was first thought that the exercise-induced IL-6 response was related to muscle damage. This finding clearly demonstrates that muscle damage is not required to provoke an increase in plasma IL-6 during exercise.
As a matter of fact, eccentric exercise may result in a delayed peak and a much slower decrease of plasma IL-6 during recovery. Recent work has shown that both upstream and downstream signalling pathways for IL-6 differ markedly between myocytes and macrophages.
IL-6, among an increasing number of other recently identified myokines, thus remains an important topic in myokine research.
It appears in muscle tissue and in the circulation during exercise at levels up to one hundred times basal rates, as noted, and is seen as having a beneficial impact on health and bodily functioning when elevated in response to physical exercise.
CD is the common signal transducer for several cytokines including leukemia inhibitory factor LIF , ciliary neurotropic factor , oncostatin M , IL and cardiotrophin-1 , and is almost ubiquitously expressed in most tissues.
In contrast, the expression of CD is restricted to certain tissues. As IL-6 interacts with its receptor, it triggers the gp and IL-6R proteins to form a complex, thus activating the receptor.
These complexes bring together the intracellular regions of gp to initiate a signal transduction cascade through certain transcription factors , Janus kinases JAKs and Signal Transducers and Activators of Transcription STATs.
IL-6 is probably the best-studied of the cytokines that use gp , also known as IL-6 signal transducer IL6ST , in their signalling complexes.
In addition to the membrane-bound receptor, a soluble form of IL-6R sIL-6R has been purified from human serum and urine. Many neuronal cells are unresponsive to stimulation by IL-6 alone, but differentiation and survival of neuronal cells can be mediated through the action of sIL-6R.
Interleukin-6 has been shown to interact with interleukin-6 receptor ,    and glycoprotein There is considerable functional overlap and interaction between Substance P SP , the natural ligand for the neurokinin type 1 receptor NK1R, a mediator of immunomodulatory activity and IL Hence, there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.
Anti-IL-6 therapy was initially developed for treatment of autoimmune diseases , but due to the role of IL-6 in chronic inflammation, IL-6 blockade was also evaluated for cancer treatment.
High IL-6 levels are associated with the development of encephalitis in children and immunodeficient mouse models infected with Enterovirus 71 ; this highly contagious virus normally causes a milder illness called Hand, foot, and mouth disease but can cause life-threatening encephalitis in some cases.
EV71 patients with a certain gene polymorphism in IL-6 also appear to be more susceptible to developing encephalitis.
IL-6 has been shown to lead to several neurological diseases through its impact on epigenetic modification within the brain.
The induction of epigenetic modification by IL-6 has been proposed as a mechanism in the pathology of schizophrenia through the hypermethylation and repression of the GAD67 promoter.
The epigenetic effects IL-6 have also been implicated in the pathology of depression. Depression is marked by altered connectivity, in particular between the anterior cingulate cortex and several other limbic areas, such as the hippocampus.
Additional preclinical and clinical data, suggest that Substance P [SP] and IL-6 may act in concert to promote major depression. SP, a hybrid neurotransmitter-cytokine, is co-transmitted with BDNF through paleo-spinothalamic circuitry from the periphery with collaterals into key areas of the limbic system.
SP and IL6 both relax tight junctions of the blood brain barrier, such that effects seen in fMRI experiments with these molecules may be a bidirectional mix of neuronal, glial, capillary, synaptic, paracrine, or endocrine-like effects.
The IL-6 antibody sirukumab is now undergoing clinical trials against major depressive disorder. Obesity is a known risk factor in the development of severe asthma.
Recent data suggests that the inflammation associated with obesity, potentially mediated by the cytokine IL6, plays a role in causing poor lung function and increased risk for developing asthma exacerbations.
From Wikipedia, the free encyclopedia. IL6 Gene location Human Chr. Chromosome 7 human . Exercise and Sport Sciences Reviews.
Journal of Applied Physiology. Compr Physiol 3 3: The Journal of Physiology. Claus Brandt and Bente K. Journal of Biomedicine and Biotechnology.
Volume , Article ID , 6 pages. Muscle as an endocrine organ: Focus on muscle-derived interleukin